Oral Presentation Australian and New Zealand Obesity Society Annual Scientific Conference 2024

The effects of anthocyanins on adiponectin in obesity: implications for inflammation and oxidative stress – A systematic literature review (#89)

Julianna Lys de Sousa Alves Neri 1 , Rannapaula Lawrynhuk Urbano Ferreira 2 , Karen Charlton 3 , Katrina Weston-Green 1
  1. Molecular Horizons and School of Medical, Indigenous and Health Sciences, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, Australia
  2. Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil
  3. School of Medical, Indigenous and Health Sciences, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, Australia

Background: Obesity is linked to reduced levels of adiponectin, an adipocyte-derived circulating protein, contributing to the development of inflammation, oxidative stress, and metabolic diseases. Strategies targeting increased production of adiponectin might be promising for preventing or improving metabolic risk factors and reducing obesity-associated metabolic disorders1,2,3. Anthocyanins are dietary bioactive compounds with antioxidant and anti-inflammatory properties4. Emerging evidence suggests that anthocyanins may increase adiponectin, which is interesting for research into novel therapies to improve inflammation and oxidative stress in obesity5,6,7. However, there is currently limited understanding of the link between the effects of anthocyanin on adiponectin in relation to inflammation and oxidative stress in obesity.

 Methodology: A systematic literature review was conducted to evaluate the effects of anthocyanins on adiponectin, inflammation, and oxidative stress in obesity. The literature search was reported according to PRISMA guidelines8 and conducted by two researchers independently using the databases PubMed, ScienceDirect, Scopus, Web of Science, and MEDLINE The protocol for this systematic review was registered on PROSPERO (CRD42023425413).

 Results: Preclinical studies (n=64), including in-vitro models of hypertrophied adipocytes (n=24) and rodent obesity-induced models (n=40), demonstrated an up-regulation of adiponectin (n=41) and SOD (n=8), and down-regulation of IL-6 (n=15), TNF-α (n=18), ROS (n=12), IL-1β (n=5), after treatment with different concentrations of anthocyanins. Clinical trials reported a significant increase in plasma adiponectin levels (n=3) and a decrease in pro-inflammatory cytokines, including TNF-α (n=4), IL-6 (n=2), and IL-10 (n=1), following supplementation with dietary anthocyanins at doses ranging from 102-165 mg/day.

 Conclusions: Clinical and preclinical evidence suggests that supplementation with dietary anthocyanins may be an effective strategy for improving circulating adiponectin, and decreasing inflammatory and oxidative stress biomarkers. Targeting a high intake of anthocyanins may be beneficial for obesity and related disorders, however, further clinical trials are needed to confirm the effects and identify optimal doses and dietary sources.

  1. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Bastard JP, Maachi M, Lagathu C, et al. https://pubmed.ncbi.nlm.nih.gov/16613757/ Eur Cytokine Netw. 2006;17:4–12.
  2. Inflammation and metabolic disorders. Hotamisligil GS. Nature. 2006;444:860–867.
  3. Systemic inflammation, adipose tissue tumor necrosis factor, and leptin expression. Bulló M, García-Lorda P, Megias I, Salas-Salvadó J. Obes Res. 2003;11:525–531.
  4. Kalt W, Cassidy A, Howard LR, Krikorian R, Stull AJ, Tremblay F, Zamora-Ros R. Recent research on the health benefits of blueberries and their anthocyanins. Advances in Nutrition. 2020 Mar 1;11(2):224-36.
  5. Krga I, Milenkovic D. Anthocyanins: From Sources and Bioavailability to Cardiovascular-Health Benefits and Molecular Mechanisms of Action. J Agric Food Chem. 2019 Feb 20;67(7):1771-1783. doi: 10.1021/acs.jafc.8b06737. Epub 2019 Feb 8. PMID: 30698008.
  6. Mattioli R, Francioso A, Mosca L, Silva P. Anthocyanins: A Comprehensive Review of Their Chemical Properties and Health Effects on Cardiovascular and Neurodegenerative Diseases. Molecules. 2020 Aug 21;25(17):3809. doi: 10.3390/molecules25173809. PMID: 32825684; PMCID: PMC7504512.
  7. Ngamsamer C, Sirivarasai J, Sutjarit N. The Benefits of Anthocyanins against Obesity-Induced Inflammation. Biomolecules. 2022 Jun 20;12(6):852. doi: 10.3390/biom12060852. PMID: 35740977.
  8. Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009 Aug 18;151(4):264-9, W64. doi: 10.7326/0003-4819-151-4-200908180-00135. Epub 2009 Jul 20.