After decades of weight loss diet trials contrasting different proportions of carbohydrates, fats and proteins, several conclusions emerge. Head to head, Low-Fat vs. Low-Carb typically results in a tie. Both approaches work for some individuals, and both approaches fail for some individuals. Diet quality, regardless of a Low-Fat or a Low-Carb focus, is likely more important than the proportions of fats and carbs. Calorie restriction is consistently a critical component of successful weight loss, but most people are inaccurate in their counting of calories – prescribed vs. achieved calorie restriction is an important differentiating feature (and will be explained). Protein calories are perhaps the most perplexing. Regardless of protein intake goals, after 6-12 months across many trials, protein intake ends up being staggeringly and stubbornly similar, at ~20% energy – wait until you see this! Instead of obsessing about macronutrients and calories, an unapologetically delicious alternative will be suggested. Taste, joy, and pleasure deserve more attention in our dietary guidance. Diet quality and social justice can be included to align with personal values and help support long-term behavior change maintenance (stealth nutrition), but we should be leading more with taste-based advice. With an engaging blend of humor and science, Professor Gardner will draw on two decades of weight loss diet experimentation to share insights and future directions.