Oral Presentation Australian and New Zealand Obesity Society Annual Scientific Conference 2024

Treatment with dual agonist improves eating behaviour in people living with overweight/obesity (#31)

Elif Ekinci 1 2 3 , Donald M Bushnell 4 , Carel W Le Roux 5 , Oren Steen 6 , Kathyrn J Lucas 7 , Meryl Brod 8 , Carl A Roberts 9 , Elena Startseva 10 , Anna Unseld 11 , Anastasia Uster 10
  1. Austin Health, Heidelberg West, VIC, Australia
  2. Australian Centre for Accelerating Diabetes Innovation, University of Melbourne, Parkville, Victoria, Australia
  3. Melbourne Medical School, University of Melbourne, Melbourne, Victoria, Australia
  4. Evidera PPD, Bethesda, MD, USA
  5. St. Vincent’s University Hospital and University College Dublin School of Medicine, Dublin, Ireland
  6. LMC Diabetes & Endocrinology, Toronto, ON, Canada
  7. Diabetes& Endocrinology Consultants PC, Morehead City, NC, USA
  8. The Brod Group, Mill Valley, CA, USA
  9. Department of Psychology, Institute of Population Health, University of Liverpool, Liverpool, West Sussex, United Kingdom
  10. Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany
  11. Boehringer Ingelheim PharmaGmbH & Co. KG, Biberach an der Riss, Germany

Background: Treatment effects on eating behaviour require further characterisation in people living with overweight/obesity. This analysis of a Phase II trial (NCT04667377) of glucagon/glucagon­like peptide-1 receptor dual agonist survodutide (Bl 456906) in adults with BMI 27 kg/m2 assessed the effect of treatment on eating behaviour using an Eating Behaviour Patient-Reported Outcome (EB PRO) measure.

Methods: The trial was a randomised, double-blind, placebo-controlled, 46-week, dose-finding study of weekly subcutaneous survodutide 0.6–4.8 mg. The EB PRO (scored as Total Eating Behaviour Score [TEBS] and two domains of Desire to Eat [DtE] and Capacity to Resist [CtR]) was assessed at Screening, Baseline, Week 20 and 46.

Results: 387 participants were randomised (treated set, N=386; full analysis set [FAS], N=384; n 77 per arm). Baseline (FAS) mean (standard deviation [SD]) age was 49.1 (12.9) years, 68.2% of participants were female, and 78.4% were White. Mean (SD) bodyweight and body mass index (BMI) were 105.7 (20.4) kg and 37.1 (6.1) kg/m2, respectively; 90.1% of participants (n=346/384) had obesity (BMI 30 kg/m2). Survodutide-treated participants showed greater improvement vs placebo in both domains at all tested doses, with the largest improvement observed in participants treated with survodutide 3.6 and 4.8 mg. Post hoc Mixed-model repeated measures analysis (n=185) revealed that survodutide (3.6 mg and 4.8 mg groups pooled) vs placebo improved adjusted DtE score (-5.15 vs -2.57), CtR score (-6.38 vs -4.23), and TEBS (-11.51 vs -6.81) at Week 46. Responder analysis showed that more survodutide-treated participants than placebo recipients had a 4-point improvement in DtE (64.7% vs 38.0%) and CtR (72.5% vs 56.0%). An 8-point improvement in TEBS was reported by 67.6% of survodutide-treated participants vs 44.0% participants on placebo.

Conclusions:  Survodutide had substantially greater efficacy vs placebo in improving eating behaviours on top of appropriate dietary and lifestyle counselling.